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Article

Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen.

Journal of molecular biology - 3 Apr 2009

Leysath Clinton E, Monzingo Arthur F, Maynard Jennifer A, Barnett Jason, Georgiou George, Iverson Brent L, Robertus Jon D

Abstract excerpt

The virulence of Bacillus anthracis is critically dependent on the cytotoxic components of the anthrax toxin, lethal factor (LF) and edema factor (EF). LF and EF gain entry into host cells through interactions with the protective antigen (PA), which binds to host cellular receptors such as CMG2. Antibodies that neutralize PA have been shown to confer protection in animal models and are undergoing intense clinical...

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Share to Antibodies, Monoclonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Bacterial

Share to Bacterial Toxins

Share to Crystallography, X-Ray

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Source

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Identifiers

PMID: 19361425
DOI: 10.1016/j.jmb.2009.02.003
PMCID: PMC2670345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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