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Analysis of the OspE Determinants Involved in Binding of Factor H and OspE-Targeting Antibodies Elicited during <i>Borrelia</i> <i>burgdorferi</i> Infection in Mice

21 May 2003

Abstract excerpt

Immune evasion by Lyme spirochetes is a multifactorial process involving numerous mechanisms. The OspE protein family undergoes antigenic variation during infection and binds factor H (fH) and possibly FHL-1/reconectin. In Borrelia burgdorferi B31MI, the OspE family consists of three paralogs: BBL39 (ErpA), BBP38, and BBN38 (ErpP). BBL39 and BBP38 are identical and therefore are referred to here as BBL39. The...

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Identifiers

PMID: 12761144
DOI: 10.1128/iai.71.6.3587-3596.2003

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