BRM Promoter Polymorphisms and Survival of Advanced Non-Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial.

doi:10.1158/1078-0432.CCR-16-1640

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Article

BRM Promoter Polymorphisms and Survival of Advanced Non-Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2017

Liu Geoffrey, Cuffe Sinead, Liang Shermi, Azad Abul Kalam, Cheng Lu, Brhane Yonathan, Qiu Xin, Cescon David W, Bruce Jeffrey, Chen Zhuo, Cheng Dangxiao, Patel Devalben, Tse Brandon C, Laurie Scott A, Goss Glenwood, Leighl Natasha B, Hung Rayjean, Bradbury Penelope A, Seymour Lesley, Shepherd Frances A, Tsao Ming Sound, Chen Bingshu E, Xu Wei, Reisman David N

Abstract excerpt

Introduction: BRM, a key catalytic subunit of the SWI/SNF chromatin remodeling complex, is a putative tumor susceptibility gene that is silenced in 15% of non-small cell lung cancer (NSCLC). Two novel BRM promoter polymorphisms (BRM-741 and BRM-1321) are associated with reversible epigenetic silencing of BRM protein expression.Experimental Design: Advanced NSCLC patients from the Princess Margaret (PM) cohort...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27827316
DOI: 10.1158/1078-0432.CCR-16-1640
PMCID: PMC5422138

Genes

HDAC9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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