Article
Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk.
Oncogene - 21 Jul 2011
Liu G, Gramling S, Munoz D, Cheng D, Azad A K, Mirshams M, Chen Z, Xu W, Roberts H, Shepherd F A, Tsao M S, Reisman D
Abstract excerpt
SWI/SNF (SWItch/sucrose non-fermentable) complexes are ATP-dependent chromatin remodeling enzymes critically involved in the regulation of multiple functions, including gene expression, differentiation, development, DNA repair, cell adhesion and cell cycle control. BRM, a key SWI/SNF complex subunit, is silenced in 15-20% of many solid tumors. As BRM-deficient mice develop 10-fold more tumors when exposed to...
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