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Article

Two functional indel polymorphisms in the promoter region of the Brahma gene (BRM) and disease risk and progression-free survival in colorectal cancer.

PloS one - 1 Jan 2018

Yu Yajun, Cheng Dangxiao, Parfrey Patrick, Liu Geoffrey, Savas Sevtap

Abstract excerpt

BACKGROUND AND OBJECTIVE: The Brahma gene (BRM) encodes a catalytic ATPase subunit of the Switch/Sucrose non-fermentable (SWI/SNF) complex, which modulates gene expression and many important cellular processes. Two indel polymorphisms in the promoter region of BRM (BRM-741 and BRM-1321) are associated with its reduced expression and the risk of susceptibility or survival outcomes in multiple solid cancers. In...

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Identifiers

PMID: 29894502
DOI: 10.1371/journal.pone.0198873
PMCID: PMC5997361

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