Article
Two BRM promoter insertion polymorphisms increase the risk of early-stage upper aerodigestive tract cancers.
Cancer medicine - 1 Apr 2014
Wong Kit Man, Qiu Xiaoping, Cheng Dangxiao, Azad Abul Kalam, Habbous Steven, Palepu Prakruthi, Mirshams Maryam, Patel Devalben, Chen Zhuo, Roberts Heidi, Knox Jennifer, Marquez Stephanie, Wong Rebecca, Darling Gail, Waldron John, Goldstein David, Leighl Natasha, Shepherd Frances A, Tsao Ming, Der Sandy, Reisman David, Liu Geoffrey
Abstract excerpt
Brahma (BRM) has a key function in chromatin remodeling. Two germline BRM promoter insertion-deletion polymorphisms, BRM-741 and BRM-1321, have been previously associated with an increased risk of lung cancer in smokers and head and neck cancer. To further evaluate their role in cancer susceptibility particularly in early disease, we conducted a preplanned case-control study to investigate the association between...
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