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Article

The reversible epigenetic silencing of BRM: implications for clinical targeted therapy.

Oncogene - 25 Oct 2007

Glaros S, Cirrincione G M, Muchardt C, Kleer C G, Michael C W, Reisman D

Abstract excerpt

The SWI/SNF chromatin-remodeling complex serves as a master switch that directs and limits the execution of specific cellular programs, such as differentiation and growth control. SWI/SNF function requires one of two paralogous ATPase subunits, Brahma (BRM) or BRM-related gene 1 (BRG1), which we previously found are lost together in cancer cell lines and primary lung cancers. Although BRG1 has been found to be...

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PMID: 17546055
DOI: 10.1038/sj.onc.1210514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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