Article
Insertion/deletion polymorphisms in the promoter region of BRM contribute to risk of hepatocellular carcinoma in Chinese populations.
PloS one - 1 Jan 2013
Gao Xueren, Huang Moli, Liu Limin, He Yan, Yu Qiang, Zhao Hua, Zhou Chunxiao, Zhang Jinkun, Zhu Zhansheng, Wan Jiao, Jiang Xinghong, Gao Yuzhen
Abstract excerpt
BACKGROUND: BRM (Brahma homologue) is well known for its critical role in tumor suppression and cancer development. Genetic variations in the promoter region of BRM have been suggested to be associated with loss of BRM expression and lung cancer risk. To the authors' knowledge, no study on the role of BRM genetic polymorphisms in hepatocellular carcinoma (HCC) risk has been performed. METHODOLOGY/PRINCIPAL...
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