Article
Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.
Cancer science - 1 Feb 2013
Matsubara Daisuke, Kishaba Yuka, Ishikawa Shumpei, Sakatani Takashi, Oguni Sachiko, Tamura Tomoko, Hoshino Hiroko, Sugiyama Yukihiko, Endo Shunsuke, Murakami Yoshinori, Aburatani Hiroyuki, Fukayama Masashi, Niki Toshiro
Abstract excerpt
BRG1 and BRM, two core catalytic subunits in SWI/SNF chromatin remodeling complexes, have been suggested as tumor suppressors, yet their roles in carcinogenesis are unclear. Here, we present evidence that loss of BRG1 and BRM is involved in the progression of lung adenocarcinomas. Analysis of 15 lung cancer cell lines indicated that BRG1 mutations correlated with loss of BRG1 expression and that loss of BRG1 and...
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