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Article

Two BRM promoter polymorphisms predict poor survival in patients with hepatocellular carcinoma.

Molecular carcinogenesis - 1 Jan 2018

Pasic Ivan, Wong Kit M, Lee Jonghun J, Espin-Garcia Osvaldo, Brhane Yonathan, Cheng Dangxiao, Chen Zhuo, Patel Devalben, Brown Catherine, Bucur Roxana, Reisman David, Knox Jennifer J, Xu Wei, Hung Rayjean J, Liu Geoffrey, Cleary Sean P

Abstract excerpt

Polymorphisms in the promoter of the BRM gene, a critical subunit of the chromatin remodeling SWI/SNF complex, have previously been implicated in risk and prognosis in Caucasian-predominant lung, head and neck, esophageal, and pancreatic cancers, and in hepatocellular cancers in Asians. We investigated the role of these polymorphisms in hepatocellular carcinoma (HCC) risk and prognosis. HCC cases were recruited...

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Identifiers

PMID: 28892201
DOI: 10.1002/mc.22736

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