Article
Association of two BRM promoter polymorphisms with head and neck squamous cell carcinoma risk.
Carcinogenesis - 1 May 2013
Wang Jennifer R, Gramling Sarah J B, Goldstein David P, Cheng Dangxiao, Chen Duoduo, Azad Abul K, Tse Alvina, Hon Henrique, Chen Zhuo, Mirshams Maryam, Simpson Colleen, Huang Shao Hui, Marquez Stephanie, O'Sullivan Brian, Liu Fei-Fei, Roberts Heidi, Xu Wei, Brown Dale H, Gilbert Ralph W, Gullane Patrick J, Irish Jonathan C, Reisman David N, Liu Geoffrey
Abstract excerpt
The SWI/SNF chromatin remodeling complex is an important regulator of gene expression that has been linked to cancer development. Expression of Brahma (BRM), a critical catalytic subunit of SWI/SNF, is lost in a variety of solid tumors. Two novel BRM promoter polymorphisms (BRM-741 and BRM-1321) have been correlated with BRM loss and elevated cancer risk. The aim(s) of this study were to examine BRM expression in...
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