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Article

Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle.

American journal of physiology. Endocrinology and metabolism - 15 May 2012

Ducommun Serge, Wang Hong Yu, Sakamoto Kei, MacKintosh Carol, Chen Shuai

Abstract excerpt

AS160 and its closely related protein TBC1D1 have emerged as key mediators for both insulin- and contraction-stimulated muscle glucose uptake through regulating GLUT4 trafficking. Insulin increases AS160 phosphorylation at multiple Akt/PKB consensus sites, including Thr(649), and promotes its bin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22318952
DOI: 10.1152/ajpendo.00379.2011
PMCID: PMC3361978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22318952-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle.PMID 22318952Read ↗

Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.Semantic proximity Read ↗

AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.Semantic proximity Read ↗

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.Semantic proximity Read ↗

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.Semantic proximity Read ↗

Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.Semantic proximity Read ↗

TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle.Semantic proximity Read ↗

PKB-Mediated Thr649 Phosphorylation of AS160/TBC1D4 Regulates the R-Wave Amplitude in the Heart.Semantic proximity Read ↗

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation.Semantic proximity Read ↗

Calmodulin binds to the Rab GTPase activating protein required for insulin-stimulated GLUT4 translocation.Semantic proximity Read ↗

The Inactivation of RabGAP Function of AS160 Promotes Lysosomal Degradation of GLUT4 and Causes Postprandial Hyperglycemia and Hyperinsulinemia.Semantic proximity Read ↗

Myo1c regulates glucose uptake in mouse skeletal muscle.Semantic proximity Read ↗

Canonical and Alternative Pathways (Insulin and Exercise) of GLUT4 Synthesis, Signaling, Intracellular Clustering, and Recruitment to the Plasma MembraneSemantic proximity Read ↗

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