Article
Orthopedic surgery increases atherosclerotic lesions and necrotic core area in ApoE-/- mice.
Atherosclerosis - 1 Dec 2016
Fuijkschot Wessel W, Morrison Martine C, van der Linden Rianne, Krijnen Paul A J, Zethof Ilse P A, Theyse Lars F H, Kleemann Robert, Niessen Hans W M, Smulders Yvo M
Abstract excerpt
BACKGROUND AND AIMS: Observational studies show a peak incidence of cardiovascular events after major surgery. For example, the risk of myocardial infarction increases 25-fold early after hip replacement. The acuteness of this increased risk suggests abrupt enhancement in plaque vulnerability, which may be related to intra-plaque inflammation, thinner fibrous cap and/or necrotic core expansion. We hypothesized...
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