Article
Ionizing radiation accelerates the development of atherosclerotic lesions in ApoE-/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage.
The American journal of pathology - 1 Feb 2006
Stewart Fiona Anne, Heeneman Sylvia, Te Poele Johannes, Kruse Jacqueline, Russell Nicola S, Gijbels Marion, Daemen Mat
Abstract excerpt
After radiotherapy treatment, there is an increased incidence of localized atherosclerosis in patients with Hodgkin's disease, breast cancer, and head and neck cancer. Here, we established a mouse model to study the development and progression of radiation-induced atherosclerosis and to compare the phenotype of these lesions with age-related atherosclerosis. Atherosclerosis-prone ApoE-/- mice fed a regular chow...
Topics
- Animals
- Apolipoproteins E
- Arteries
- Atherosclerosis
- C-Reactive Protein
- Cholesterol
- Diet
- Disease Models, Animal
- Disease Susceptibility
- Female
- Granulocytes
- Hemorrhage
- Homozygote