Article
Comprehensive analysis of 1-year-old apolipoprotein E-deficient mice reveals advanced atherosclerosis with vulnerable plaque characteristics.
2023-02-16
Abstract excerpt
Apolipoprotein E-knockout (Apoe-/-) mice constitute the most widely employed animal model of atherosclerosis. Deletion of Apoe induces profound hypercholesterolemia and promotes the development of atherosclerosis. However, despite its widespread use, the Apoe-/-mouse model remains incompletely characterized, especially at late time points and advanced disease states. Thus, it is unclear how late atherosclerotic pl...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 3aecde39-6489-5aeb-b3bd-fa3f94bc6812
- DOI
- 10.21203/rs.3.rs-2510575/v1