Article

Postoperative Stress Accelerates Atherosclerosis through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

2025-05-04

Abstract excerpt

<h4>BACKGROUND</h4> Over 10 million patients undergoing non-cardiac surgery annually experience major cardiovascular complications within 30 days, many due to destabilized atherosclerotic plaques. Reverse cholesterol transport (RCT), a key pathway for cholesterol removal by HDL and apoA-I, is critical in preventing plaque progression. While surgery-induced inflammation is known to impair HDL function, its effects...

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Literature Corpus work: 34667681-ebc5-5558-8c80-202260f31723
DOI: 10.1101/2025.05.02.651357

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