Article
Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia.
Angiology - 1 Feb 2016
Awan Zuhier, Denis Maxime, Roubtsova Anna, Essalmani Rachid, Marcinkiewicz Jadwiga, Awan Amani, Gram Hermann, Seidah Nabil G, Genest Jacques
Abstract excerpt
BACKGROUND: Given the link between cholesterol and activation of inflammation via interleukin 1β (IL-1β), we tested the effects of IL-1β inhibition on atherosclerotic calcification in mice. Patients with familial hypercholesterolemia develop extensive aortic calcification and calcific aortic stenosis. Although statins delay this process, low-density lipoprotein (LDL) cholesterol lowering alone is not enough to...
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