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Article

Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice.

Circulation research - 7 Nov 2008

Moura Rute, Tjwa Marc, Vandervoort Petra, Van Kerckhoven Soetkin, Holvoet Paul, Hoylaerts Marc F

Abstract excerpt

Thrombospondin (TSP)1 is implicated in various inflammatory processes, but its role in atherosclerotic plaque formation and progression is unclear. Therefore, the development of atherosclerosis was compared in ApoE(-/-) and Tsp1(-/-)ApoE(-/-) mice kept on a normocholesterolemic diet. At 6 months, morphometric analysis of the aortic root of both mouse genotypes showed comparable lesion areas. Even when plaque...

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Source

Identifiers

PMID: 18818405
DOI: 10.1161/CIRCRESAHA.108.185645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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