Article
Sickle Cell Anemia Mediates Carotid Artery Expansive Remodeling That Can Be Prevented by Inhibition of JNK (c-Jun N-Terminal Kinase).
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2020
Song Hannah, Keegan Philip M, Anbazhakan Suhaas, Rivera Christian P, Feng Yundi, Omojola Victor O, Clark Alexus A, Cai Shuangyi, Selma Jada, Gleason Rudolph L, Botchwey Edward A, Huo Yunlong, Tan Wenchang, Platt Manu O
Abstract excerpt
OBJECTIVE: Sickle cell anemia (SCA) causes chronic inflammation and multiorgan damage. Less understood are the arterial complications, most evident by increased strokes among children. Proteolytic mechanisms, biomechanical consequences, and pharmaceutical inhibitory strategies were studied in a mouse model to provide a platform for mechanistic and intervention studies of large artery damage due to sickle cell...
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