Article
Serum Amyloid A Facilitates Early Lesion Development in Ldlr-/- Mice.
Journal of the American Heart Association - 17 Jul 2015
Krishack Paulette A, Bhanvadia Clarissa V, Lukens John, Sontag Timothy J, De Beer Maria C, Getz Godfrey S, Reardon Catherine A
Abstract excerpt
BACKGROUND: Atherosclerosis is a chronic inflammatory disorder, and several studies have demonstrated a positive association between plasma serum amyloid A (SAA) levels and cardiovascular disease risk. The aim of the study was to examine whether SAA has a role in atherogenesis, the underlying basis of most cardiovascular disease. METHODS AND RESULTS: Mice globally deficient in acute-phase isoforms Saa1 and Saa2...
Topics
- Animals
- Aorta
- Aortic Diseases
- Atherosclerosis
- Bone Marrow Transplantation
- Diet, High-Fat
- Disease Models, Animal
- Disease Progression
- Female
- Foam Cells
- Genotype
- Lipids
- Macrophages, Peritoneal
- Mice, Inbred C57BL