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Article

Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer.

Reproductive biology and endocrinology : RB&E - 8 Nov 2016

Cheng Wenmin, Zhao Heng, Yu Honghao, Xin Jige, Wang Jia, Zeng Luyao, Yuan Zaimei, Qing Yubo, Li Honghui, Jia Baoyu, Yang Cejun, Shen Youfeng, Zhao Lu, Pan Weirong, Zhao Hong-Ye, Wang Wei, Wei Hong-Jiang

Abstract excerpt

BACKGROUND: α1,3-Galactosyltransferase (GGTA1) is essential for the biosynthesis of glycoproteins and therefore a simple and effective target for disrupting the expression of galactose α-1,3-galactose epitopes, which mediate hyperacute rejection (HAR) in xenotransplantation. Miniature pigs are considered to have the greatest potential as xenotransplantation donors. A GGTA1-knockout (GTKO) miniature pig might...

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Share to Galactosyltransferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Graft Rejection

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Share to Transcription Activator-Like Effector Nucleases

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Source

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Identifiers

PMID: 27821126
DOI: 10.1186/s12958-016-0212-7
PMCID: PMC5100250

Genes

GGTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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