Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs.

PloS one - 1 Jan 2013

Xin Jige, Yang Huaqiang, Fan Nana, Zhao Bentian, Ouyang Zhen, Liu Zhaoming, Zhao Yu, Li Xiaoping, Song Jun, Yang Yi, Zou Qingjian, Yan Quanmei, Zeng Yangzhi, Lai Liangxue

Abstract excerpt

Inbred mini-pigs are ideal organ donors for future human xenotransplantations because of their clear genetic background, high homozygosity, and high inbreeding endurance. In this study, we chose fibroblast cells from a highly inbred pig line called Banna mini-pig inbred line (BMI) as donor nuclei for nuclear transfer, combining with transcription activator-like effector nucleases (TALENs) and successfully...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Galactosyltransferases

Share to Gene Knockout Techniques

Share to Gene Targeting

Share to Swine, Miniature

Source

Open in PubMed Open full text

Identifiers

PMID: 24358349
DOI: 10.1371/journal.pone.0084250
PMCID: PMC3866186

Genes

GGTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs.PMID 24358349Read ↗

Highly efficient generation of GGTA1 knockout pigs using a combination of TALEN mRNA and magnetic beads with somatic cell nuclear transferSemantic proximity Read ↗

Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer.Semantic proximity Read ↗

Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer.Semantic proximity Read ↗

Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer.Semantic proximity Read ↗

Production of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technologySemantic proximity Read ↗

Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs.Semantic proximity Read ↗

Efficient production of biallelic <i><scp>GGTA</scp>1</i> knockout pigs <i>by</i> cytoplasmic microinjection of <scp>CRISPR</scp>/Cas9 into zygotesSemantic proximity Read ↗

Efficient generation of GGTA1-deficient pigs by electroporation of the CRISPR/Cas9 system into in vitro-fertilized zygotes.Semantic proximity Read ↗

Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs.Semantic proximity Read ↗

Optimization Strategy for Generating Gene-edited Tibet Minipigs by Synchronized Oestrus and Cytoplasmic Microinjection.Semantic proximity Read ↗

Efficient biallelic mutation in porcine parthenotes using a CRISPR-Cas9 system.Semantic proximity Read ↗

Genome-wide Genetic Mutations Accumulated in Pigs Genome-edited for Xenotransplantation and Their Filial Generation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.