Article
HLA-G1+ Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses.
Frontiers in immunology - 1 Jan 2021
Rao Joseph Sushil, Hosny Nora, Kumbha Ramesh, Naqvi Raza Ali, Singh Amar, Swanson Zachary, Levy Heather, Matson Anders W, Steinhoff Magie, Forneris Nicole, Walters Eric, Hering Bernhard J, Burlak Christopher
Abstract excerpt
The human leukocyte antigen G1 (HLA-G1), a non-classical class I major histocompatibility complex (MHC-I) protein, is a potent immunomodulatory molecule at the maternal/fetal interface and other environments to regulate the cellular immune response. We created GGTA1-/HLAG1+ pigs to explore their use as organ and cell donors that may extend xenograft survival and function in both preclinical nonhuman primate (NHP)...
Topics
- Animals
- Animals, Genetically Modified
- B-Lymphocytes
- Blood Glucose
- Cell Proliferation
- Cells, Cultured
- Coculture Techniques
- Fibroblasts
- Galactosyltransferases
- Genotype