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Article

Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr-/- mice.

Atherosclerosis - 1 Dec 2016

Jeurissen Mike L J, Walenbergh Sofie M A, Houben Tom, Gijbels Marion J J, Li Jieyi, Hendrikx Tim, Oligschlaeger Yvonne, van Gorp Patrick J, Binder Christoph J, Donners Marjo M P C, Shiri-Sverdlov Ronit

Abstract excerpt

BACKGROUND AND AIMS: Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifically between the oxidized type of LDL (oxLDL) and atherosclerotic lesion formation. Further...

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Identifiers

PMID: 27816810
DOI: 10.1016/j.atherosclerosis.2016.10.038

Genes

NPC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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