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Article

Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.

PloS one - 1 Jan 2016

Cheng Fei, Twardowski Laura, Reifenberg Kurt, Winter Kerstin, Canisius Antje, Pross Eva, Fan Jianglin, Schmitt Edgar, Shultz Leonard D, Lackner Karl J, Torzewski Michael

Abstract excerpt

This study focused on the unique properties of both the Ldlr knockout defect (closely mimicking the human situation) and the BALB/c (C) inbred mouse strain (Th-2 slanted immune response). We generated two immunodeficient strains with severe combined B- and T-cell immunodeficiency with or without a complete lack of natural killer cells to revisit the role of adaptive immune responses on atherogenesis. C-Ldlr-/-...

Read the complete abstract on PubMed

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Share to Adaptive Immunity
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune System

Share to Immunologic Deficiency Syndromes

Share to Killer Cells, Natural

Share to Lipoproteins

Share to Plaque, Atherosclerotic

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 27564380
DOI: 10.1371/journal.pone.0157311
PMCID: PMC5001715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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