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Article

LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma.

Journal of lipid research - 1 Aug 2009

Schaeffer David F, Riazy Maziar, Parhar Kuljit S, Chen Johnny H, Duronio Vincent, Sawamura Tatsuya, Steinbrecher Urs P

Abstract excerpt

Oxidized LDL (oxLDL) promotes lipid accumulation as well as growth and survival signaling in macrophages. OxLDL uptake is mainly due to scavenger receptors SR-AI/II and CD36. However, other scavenger receptors such as lectin-like oxLDL receptor-1 (LOX-1) may also play a role. We used mice with ta...

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Share to Biological Transport
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Share to Lipoproteins, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Macrophages, Peritoneal

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Share to Proto-Oncogene Proteins c-akt

Share to Scavenger Receptors, Class E

Source

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Identifiers

PMID: 19359704
DOI: 10.1194/jlr.M900167-JLR200
PMCID: PMC2724041

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19359704-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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