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Article

PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice.

Atherosclerosis - 1 Sept 2018

Yu Pei, Qian Alexander S, Chathely Kevin M, Trigatti Bernardo L

Abstract excerpt

BACKGROUND AND AIMS: PDZK1 (Post-synaptic density protein/Drosophila disc-large protein/Zonula occludens protein containing 1) stabilizes the HDL receptor protein, SR-B1, in the liver, and mediates SR-B1 signaling outside of the liver. Complete knockout of pdzk1 increases atherosclerosis in apoE-deficient mice, but the effect of PDZK1 in leukocytes is not known. In this study, we tested the role of leukocyte...

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Share to Bone Marrow Transplantation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lipoproteins, HDL

Share to Macrophages, Peritoneal

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Share to Plaque, Atherosclerotic

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Source

Identifiers

PMID: 29853191
DOI: 10.1016/j.atherosclerosis.2018.05.009

Genes

PDZK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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