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Article

PAC1 deficiency attenuates progression of atherosclerosis in ApoE deficient mice under cholesterol-enriched diet.

Immunobiology - 1 May 2020

Splitthoff Paul, Rasbach Erik, Neudert Philip, Bonaterra Gabriel A, Schwarz Anja, Mey Lilli, Schwarzbach Hans, Eiden Lee E, Weihe Eberhard, Kinscherf Ralf

Abstract excerpt

The neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP) is vasoactive and cytoprotective and exerts immunoregulatory functions throughout the nervous, neuroendocrine cardiovascular and immune systems in health and disease. PACAP mainly acts through PAC1 receptor signaling in neuronal communication, but the role of PAC1 in immune regulation of atherosclerosis is not known. Here, we generated...

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Identifiers

PMID: 32173151
DOI: 10.1016/j.imbio.2020.151930
PMCID: PMC9741700

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