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Article

Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging.

Acta neuropathologica - 1 Dec 2016

Nelson Peter T, Katsumata Yuriko, Nho Kwangsik, Artiushin Sergey C, Jicha Gregory A, Wang Wang-Xia, Abner Erin L, Saykin Andrew J, Kukull Walter A, Fardo David W

Abstract excerpt

We report evidence of a novel pathogenetic mechanism in which thyroid hormone dysregulation contributes to dementia in elderly persons. Two single nucleotide polymorphisms (SNPs) on chromosome 12p12 were the initial foci of our study: rs704180 and rs73069071. These SNPs were identified by separate research groups as risk alleles for non-Alzheimer's neurodegeneration. We found that the rs73069071 risk genotype was...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27815632
DOI: 10.1007/s00401-016-1641-2
PMCID: PMC5154615

Genes

ABCC9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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