Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target.

Ageing research reviews - 1 Nov 2015

Nelson Peter T, Jicha Gregory A, Wang Wang-Xia, Ighodaro Eseosa, Artiushin Sergey, Nichols Colin G, Fardo David W

Abstract excerpt

The ABCC9 gene and its polypeptide product, SUR2, are increasingly implicated in human neurologic disease, including prevalent diseases of the aged brain. SUR2 proteins are a component of the ATP-sensitive potassium ("KATP") channel, a metabolic sensor for stress and/or hypoxia that has been shown to change in aging. The KATP channel also helps regulate the neurovascular unit. Most brain cell types express SUR2,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Brain Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomegaly

Share to Hippocampus

Share to Hypertrichosis

Share to Mutation

Share to Osteochondrodysplasias

Share to Sulfonylurea Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 26226329
DOI: 10.1016/j.arr.2015.07.007
PMCID: PMC4661124

Genes

ABCC9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target.PMID 26226329Read ↗

Novel human ABCC9/SUR2 brain-expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging.Semantic proximity Read ↗

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.Semantic proximity Read ↗

The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic reviewSemantic proximity Read ↗

The ABC's of Alzheimer risk gene ABCA7.Semantic proximity Read ↗

ABCC8 Single Nucleotide Polymorphisms are Associated with Cerebral Edema in Severe TBI.Semantic proximity Read ↗

Alteration in the Function and Expression of SLC and ABC Transporters in the Neurovascular Unit in Alzheimer’s Disease and the Clinical SignificanceSemantic proximity Read ↗

Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging.Semantic proximity Read ↗

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9Semantic proximity Read ↗

The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds.Semantic proximity Read ↗

ABC Transporters and the Alzheimer’s Disease EnigmaSemantic proximity Read ↗

ABCA7 and Pathogenic Pathways of Alzheimer’s DiseaseSemantic proximity Read ↗

Cholesterol in brain disease: sometimes determinant and frequently implicated.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.