Article
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
Acta neuropathologica - 1 Jan 2014
Nelson Peter T, Estus Steven, Abner Erin L, Parikh Ishita, Malik Manasi, Neltner Janna H, Ighodaro Eseosa, Wang Wang-Xia, Wilfred Bernard R, Wang Li-San, Kukull Walter A, Nandakumar Kannabiran, Farman Mark L, Poon Wayne W, Corrada Maria M, Kawas Claudia H, Cribbs David H, Bennett David A, Schneider Julie A, Larson Eric B, Crane Paul K, Valladares Otto, Schmitt Frederick A, Kryscio Richard J, Jicha Gregory A, Smith Charles D, Scheff Stephen W, Sonnen Joshua A, Haines Jonathan L, Pericak-Vance Margaret A, Mayeux Richard, Farrer Lindsay A, Van Eldik Linda J, Horbinski Craig, Green Robert C, Gearing Marla, Poon Leonard W, Kramer Patricia L, Woltjer Randall L, Montine Thomas J, Partch Amanda B, Rajic Alexander J, Richmire KatieRose, Monsell Sarah E, Schellenberg Gerard D, Fardo David W
Abstract excerpt
Hippocampal sclerosis of aging (HS-Aging) is a high-morbidity brain disease in the elderly but risk factors are largely unknown. We report the first genome-wide association study (GWAS) with HS-Aging pathology as an endophenotype. In collaboration with the Alzheimer's Disease Genetics Consortium, data were analyzed from large autopsy cohorts: (#1) National Alzheimer's Coordinating Center (NACC); (#2) Rush...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.