Article
Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2025
Godrich Dana, Pasteris Jeremy, Martin Eden R, Kunkle Brian, Naj Adam C, Hamilton Kara, Wang Hui, Lee Wan-Ping, Dumitrescu Logan, Hohman Timothy J, Mayeux Richard, Larson Eric B, Crane Paul K, Keene C Dirk, Latimer Caitlin, Mukherjee Shubhabrata, Kofler Julia, Kamboh M Ilyas, Bennett David A, Molina-Porcel Laura, Schellenberg Gerard, Pericak-Vance Margaret A, Cuccaro Michael, Scott William K, Rundek Tatjana, Kukull Walter, Montine Thomas, Beecham Gary W
Abstract excerpt
INTRODUCTION: Transactive response DNA binding protein 43 kDa (TDP-43) proteinopathy has been linked to cognitive decline and often co-occurs with hippocampal sclerosis (HS). To identify genetic markers of TDP-43 proteinopathy and HS, we performed genome-wide association studies (GWASs) of HS and TDP-43 inclusions. METHODS: Genetic data were obtained through the Alzheimer Disease Genetics Consortium and...
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