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Article

TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels.

Neurobiology of disease - 1 May 2019

Nelson Peter T, Gal Zsombor, Wang Wang-Xia, Niedowicz Dana M, Artiushin Sergey C, Wycoff Samuel, Wei Angela, Jicha Gregory A, Fardo David W

Abstract excerpt

TDP-43 proteinopathy is very prevalent among the elderly (affecting at least 25% of individuals over 85 years of age) and is associated with substantial cognitive impairment. Risk factors implicated in age-related TDP-43 proteinopathy include commonly inherited gene variants, comorbid Alzheimer's disease pathology, and thyroid hormone dysfunction. To test parameters that are associated with aging-related TDP-43...

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Source

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Identifiers

PMID: 30682540
DOI: 10.1016/j.nbd.2019.01.013
PMCID: PMC6696921

Genes

ABCC9
IAPP
SLCO1A2
SLCO1C1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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