Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology.

doi:10.1007/s12031-015-0666-7

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Article

Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology.

Journal of molecular neuroscience : MN - 1 Jan 2016

Leduc Valerie, Théroux Louise, Dea Doris, Dufour Robert, Poirier Judes

Abstract excerpt

3-Hydroxy-3-methyglutaryl coenzyme A reductase (HMGCR) is a cholesterol-regulating gene with statin relevance. rs3846662 being involved in regulation of HMGCR alternative splicing, we explored its impact on HMGCR messenger RNA (mRNA) and protein levels in the brain and the associations between those levels and levels of Alzheimer's disease pathological markers. We used brain samples derived from a cohort of 33...

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PMID: 26541602
DOI: 10.1007/s12031-015-0666-7
PMCID: PMC5138059

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HMGCR

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