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Article

Putative risk alleles for LATE‐NC with hippocampal sclerosis in population‐representative autopsy cohorts

3 Aug 2019

Abstract excerpt

Abstract Limbic‐predominant age‐related TAR‐DNA‐binding protein‐43 (TDP‐43) encephalopathy with hippocampal sclerosis pathology (LATE‐NC + HS) is a neurodegenerative disorder characterized by severe hippocampal CA1 neuron loss and TDP‐43‐pathology, leading to cognitive dysfunction and dementia. Polymorphisms in GRN, TMEM106B and ABCC9 are proposed as LATE‐NC + HS risk factors in brain bank collections. To...

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PMID: 31376286
DOI: 10.1111/bpa.12773

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