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A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

Cell - 3 Nov 2016

Li Yang, Oosting Marije, Smeekens Sanne P, Jaeger Martin, Aguirre-Gamboa Raul, Le Kieu T T, Deelen Patrick, Ricaño-Ponce Isis, Schoffelen Teske, Jansen Anne F M, Swertz Morris A, Withoff Sebo, van de Vosse Esther, van Deuren Marcel, van de Veerdonk Frank, Zhernakova Alexandra, van der Meer Jos W M, Xavier Ramnik J, Franke Lude, Joosten Leo A B, Wijmenga Cisca, Kumar Vinod, Netea Mihai G

Abstract excerpt

As part of the Human Functional Genomics Project, which aims to understand the factors that determine the variability of immune responses, we investigated genetic variants affecting cytokine production in response to ex vivo stimulation in two independent cohorts of 500 and 200 healthy individuals. We demonstrate a strong impact of genetic heritability on cytokine production capacity after challenge with...

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PMID: 27814507
DOI: 10.1016/j.cell.2016.10.017

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TLR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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