Article
Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses.
Genome medicine - 25 May 2021
van Deuren Rosanne C, Arts Peer, Cavalli Giulio, Jaeger Martin, Steehouwer Marloes, van de Vorst Maartje, Gilissen Christian, Joosten Leo A B, Dinarello Charles A, Mhlanga Musa M, Kumar Vinod, Netea Mihai G, van de Veerdonk Frank L, Hoischen Alexander
Abstract excerpt
BACKGROUND: The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation. Both common and rare genetic variation in this pathway underlies various inflammation-mediated diseases, but the role of rare variants relative to common variants in immune response variability in healthy individuals remains unclear. METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.