Article

Impact of rare and common genetic variation in the Interleukin-1 pathway on human cytokine responses

2020-02-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Interleukin(IL)-1 signaling is of major importance in human innate cytokine responses. Common variants in related genes have been linked to various inflammation-mediated diseases and stimulation-induced cytokine responses, but the role of rare variants remains to be elucidated. <h4>Methods</h4> In this study, we characterize the role of rare and common genetic variation, as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6211aaa7-ed47-5224-bc5c-29a0be1f8d0e
DOI: 10.1101/2020.02.14.949602

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of rare and common genetic variation in the Interleukin-1 pathway on human cytokine responsesDOI 10.1101/2020.02.14.949602Read

Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses.Semantic proximity Read

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.Semantic proximity Read

Genetically downregulated interleukin-6 signaling is associated with a favorable cardiometabolic profile: a phenome-wide association studySemantic proximity Read

Transcription-based identification of uncharacterized genes in the human immune responseSemantic proximity Read

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.Semantic proximity Read

Differential Associations of Interleukin 6 Receptor Variant Across Genetic Ancestries and Implications for Targeted TherapiesSemantic proximity Read

A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections.Semantic proximity Read

Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Semantic proximity Read

IL-1 signaling enrichment in inflammatory skin disease loci with higher risk allele frequencies in African ancestrySemantic proximity Read

The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs).Semantic proximity Read

Rare variants in infection response protein pathways associated with sepsis in childrenSemantic proximity Read

The Genomic Architecture of Circulating Cytokine Levels Points to Drug Targets for Immune-Related DiseasesSemantic proximity Read