Article
A functional genomics approach in Tanzanian population identifies distinct genetic regulators of cytokine production compared to European population.
American journal of human genetics - 3 Mar 2022
Boahen Collins K, Temba Godfrey S, Kullaya Vesla I, Matzaraki Vasiliki, Joosten Leo A B, Kibiki Gibson, Mmbaga Blandina T, van der Ven Andre, de Mast Quirijn, Netea Mihai G, Kumar Vinod
Abstract excerpt
Humans exhibit remarkable interindividual and interpopulation immune response variability upon microbial challenges. Cytokines play a vital role in regulating inflammation and immune responses, but dysregulation of cytokine responses has been implicated in different disease states. Host genetic factors were previously shown to significantly impact cytokine response heterogeneity mainly in European-based studies,...
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