Article

A single-cell cytokine dictionary of human peripheral blood

2025-12-15

Abstract excerpt

Cytokines orchestrate immune responses, yet we still lack a comprehensive understanding of their specific effects across human immune cells due to their pleiotropy, context dependence and extensive functional redundancy. Here, we present a Human Cytokine Dictionary, created from high-resolution single-cell transcriptomes of 9,697,974 human peripheral blood mononuclear cells (PBMC) from 12 donors stimulated in vit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad6cabcb-d7d0-5b97-88fa-83c92b2a9a7d
DOI: 10.64898/2025.12.12.693897

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single-cell cytokine dictionary of human peripheral bloodDOI 10.64898/2025.12.12.693897Read

A single-cell cytokine dictionary of human peripheral bloodSemantic proximity Read

Global landscape of mouse and human cytokine transcriptional regulationSemantic proximity Read

A human cytokine response atlas to reconstruct underlying gene regulatory networksSemantic proximity Read

Interpretable Inflammation Landscape of Circulating Immune cellsSemantic proximity Read

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasSemantic proximity Read

CytokineFindeR: an R-package for benchmarking methods and databases for identifying cytokinesSemantic proximity Read

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasSemantic proximity Read

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass CytometrySemantic proximity Read

CytokineLink: a cytokine communication map to analyse immune responses in inflammatory and infectious diseasesSemantic proximity Read

Decipher: A computational pipeline to extract context-specific mechanistic insights from single-cell profilesSemantic proximity Read

IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation.Semantic proximity Read

Comprehensive mapping of the human cytokine gene regulatory networkSemantic proximity Read