Article
Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.
Nature immunology - 1 Jul 2018
Bakker Olivier B, Aguirre-Gamboa Raul, Sanna Serena, Oosting Marije, Smeekens Sanne P, Jaeger Martin, Zorro Maria, Võsa Urmo, Withoff Sebo, Netea-Maier Romana T, Koenen Hans J P M, Joosten Irma, Xavier Ramnik J, Franke Lude, Joosten Leo A B, Kumar Vinod, Wijmenga Cisca, Netea Mihai G, Li Yang
Abstract excerpt
The immune response to pathogens varies substantially among people. Whereas both genetic and nongenetic factors contribute to interperson variation, their relative contributions and potential predictive power have remained largely unknown. By systematically correlating host factors in 534 healthy volunteers, including baseline immunological parameters and molecular profiles (genome, metabolome and gut...
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