Article

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

2019-02-08

Abstract excerpt

Cytokines are essential regulatory components of the immune system and their aberrant levels have been linked to many disease states. Despite increasing evidence that cytokines operate in concert, many of the physiological interactions between cytokines, and the shared genetic architecture that underlie them, remain unknown. Here we aimed to identify and characterise genetic variants with pleiotropic effects on cy...

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Literature Corpus work: d6b5c55b-155b-5c6a-9b5a-0881dbe38c3c
DOI: 10.1101/544445

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