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Genome-wide association study identifies 17 new loci influencing concentrations of circulating cytokines and growth factors

2016-03-25

Abstract excerpt

Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide association study (GWAS) up to n=8,293 Finns we identified 27 loci with genome-wide association (P-value<1.2×10 -9 ) for one or more cytokines, including 17 unidentified in previous GWASes. Fifteen of the associated SNPs had expression quantitative trait loci i...

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Literature Corpus work
c5b01e91-ddf3-5f09-94fb-a475c2b22dea
DOI
10.1101/045005
Open publication

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