Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation.

doi:10.1182/blood-2016-06-722249

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Article

Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation.

Blood - 26 Jan 2017

Cunha Renato, Zago Marco A, Querol Sergio, Volt Fernanda, Ruggeri Annalisa, Sanz Guillermo, Pouthier Fabienne, Kogler Gesine, Vicario José L, Bergamaschi Paola, Saccardi Riccardo, Lamas Carmen H, Díaz-de-Heredia Cristina, Michel Gerard, Bittencourt Henrique, Tavella Marli, Panepucci Rodrigo A, Fernandes Francisco, Pavan Julia, Gluckman Eliane, Rocha Vanderson

Abstract excerpt

We evaluated the impact of recipient and cord blood unit (CBU) genetic polymorphisms related to immune response on outcomes after unrelated cord blood transplantations (CBTs). Pretransplant DNA samples from 696 CBUs with malignant diseases were genotyped for NLRP1, NLRP2, NLRP3, TIRAP/Mal, IL10, REL, TNFRSF1B, and CTLA4. HLA compatibility was 6 of 6 in 10%, 5 of 6 in 39%, and ≥4 of 6 in 51% of transplants....

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Identifiers

PMID: 27811020
DOI: 10.1182/blood-2016-06-722249

Genes

CTLA4
NRM
NLRP1
NLRP2
NLRP3
REL
TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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