Association of donor IFNL4 genotype and non-relapse mortality after unrelated donor myeloablative haematopoietic stem-cell transplantation for acute leukaemia: a retrospective cohort study.

doi:10.1016/S2352-3026(20)30294-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association of donor IFNL4 genotype and non-relapse mortality after unrelated donor myeloablative haematopoietic stem-cell transplantation for acute leukaemia: a retrospective cohort study.

The Lancet. Haematology - 1 Oct 2020

Gadalla Shahinaz M, Wang Youjin, Wang Tao, Onabajo Olusegun O, Banday A Rouf, Obajemu Adeola, Karaesman Ezgi, Sucheston-Campbell Lara, Hahn Theresa, Sees Jennifer A, Spellman Stephen R, Lee Stephanie J, Katki Hormuzd A, Prokunina-Olsson Ludmila

Abstract excerpt

BACKGROUND: The interferon lambda 4 gene (IFNL4) regulates immune responses by controlling the production of IFNλ4, a type III interferon. We hypothesised that IFNλ4 could play a role in infection clearance or alloreactivity in patients with acute leukaemia who received a myeloablative 10/10 HLA-matched haematopoietic stem-cell transplantation (HSCT). Therefore, we aimed to assess the association between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukins

Share to Leukemia, Myeloid, Acute

Share to Polymorphism, Single Nucleotide

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Treatment Outcome

Share to Unrelated Donors

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 32976751
DOI: 10.1016/S2352-3026(20)30294-5
PMCID: PMC7735535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of donor IFNL4 genotype and non-relapse mortality after unrelated donor myeloablative haematopoietic stem-cell transplantation for acute leukaemia: a retrospective cohort study.PMID 32976751Read ↗

Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation.Semantic proximity Read ↗

Genetic variation in donor CTLA-4 regulatory region is a strong predictor of outcome after allogeneic hematopoietic cell transplantation for hematologic malignancies.Semantic proximity Read ↗

Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight.Semantic proximity Read ↗

Single nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study.Semantic proximity Read ↗

Donor Genetic Predisposition to High Interleukin-10 Production Appears Protective against Acute Graft-Versus-Host Disease.Semantic proximity Read ↗

Donor-Recipient Matching for KIR Genotypes Reduces Chronic GVHD and Missing Inhibitory KIR Ligands Protect against Relapse after Myeloablative, HLA Matched Hematopoietic Cell Transplantation.Semantic proximity Read ↗

The recipient CXCL10 + 1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation.Semantic proximity Read ↗

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies.Semantic proximity Read ↗

IFNL4 and donor selection for matched unrelated donor haematopoietic stem-cell transplantation.Semantic proximity Read ↗

Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation.Semantic proximity Read ↗

Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: a center for international blood and marrow transplant research analysis.Semantic proximity Read ↗

The recipient CCR5 variation predicts survival outcomes after bone marrow transplantation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.