Article
Genetic variation in donor CTLA-4 regulatory region is a strong predictor of outcome after allogeneic hematopoietic cell transplantation for hematologic malignancies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jul 2012
Jagasia Madan, Clark William B, Brown-Gentry Kristin D, Crawford Dana C, Fan Kang-Hsien, Chen Heidi, Kassim Adetola, Greer John P, Engelhardt Brian G, Savani Bipin N
Abstract excerpt
Relapse remains a major cause of death after allogeneic hematopoietic cell transplantation (allo-HCT). Graft-versus-tumor effect is primarily mediated by donor T cells. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a critical inhibitor of T cell proliferation. Single nucleotide polymorphisms (SNPs) in CTLA-4 may affect immune responses. We hypothesized that CTLA-4 SNPs will be associated with disease control after...
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