Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: a center for international blood and marrow transplant research analysis.

doi:10.1016/j.bbmt.2014.03.005

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Article

Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: a center for international blood and marrow transplant research analysis.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jun 2014

Sengsayadeth Salyka, Wang Tao, Lee Stephanie J, Haagenson Michael D, Spellman Stephen, Fernandez Viña Marcelo A, Muller Carlheinz R, Verneris Michael R, Savani Bipin N, Jagasia Madan

Abstract excerpt

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays an essential role in T cell homeostasis by restraining immune responses. AG and GG genotypes of donor CTLA-4 SNP rs4553808 in patients after unrelated donor hematopoietic stem cell transplantations (HSCT) have been shown to be an independent predictor of inferior relapse-free survival (RFS) and overall survival (OS) compared with those with the AA genotype, in...

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PMID: 24631737
DOI: 10.1016/j.bbmt.2014.03.005
PMCID: PMC4034271

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