Effect of IL-2 polymorphism rs2069762 on single-unit cord blood transplant outcomes.

doi:10.1016/j.cyto.2024.156636

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Article

Effect of IL-2 polymorphism rs2069762 on single-unit cord blood transplant outcomes.

Cytokine - 1 Jul 2024

Konuma Takaaki, Hamatani-Asakura Megumi, Monna-Oiwa Maki, Kato Seiko, Isobe Masamichi, Yokoyama Kazuaki, Takahashi Satoshi, Nannya Yasuhito

Abstract excerpt

BACKGROUND: Interleukin-2 (IL-2) is one of the most important cytokines that regulate the activation and proliferation of T cells and natural killer cells. The production of IL-2 may be affected by polymorphisms in the promoter region of the IL-2 gene (rs2069762). In allogeneic hematopoietic cell transplantation (HCT) from adult donors, rs2069762 has been associated with the incidence of acute and chronic...

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PMID: 38718489
DOI: 10.1016/j.cyto.2024.156636

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