Article
Recipient IL-17A polymorphism rs2275913 is associated with acute graft-versus-host disease after single-unit cord blood transplantation.
Transplant immunology - 1 Oct 2024
Konuma Takaaki, Hamatani-Asakura Megumi, Monna-Oiwa Maki, Kato Seiko, Andoh Shohei, Yokoyama Kazuaki, Nannya Yasuhito, Takahashi Satoshi
Abstract excerpt
BACKGROUND: Interleukin-17 (IL-17) is elevated in human inflammatory and autoimmune diseases. The polymorphism in the promoter region of the IL-17 A gene is associated with susceptibility to several inflammatory diseases, including acute graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation from adult donors. However, the impacts of IL-17 A polymorphism on cord blood...
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