Article
Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy.
Blood - 2 Jan 2014
Eapen Mary, Klein John P, Ruggeri Annalisa, Spellman Stephen, Lee Stephanie J, Anasetti Claudio, Arcese William, Barker Juliet N, Baxter-Lowe Lee Ann, Brown Maria, Fernandez-Vina Marcelo A, Freeman John, He Wensheng, Iori Anna Paola, Horowitz Mary M, Locatelli Franco, Marino Susana, Maiers Martin, Michel Gerard, Sanz Guillermo F, Gluckman Eliane, Rocha Vanderson
Abstract excerpt
We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16% at 4, and 5% at 5 alleles. In a subset, allele-level HLA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.